Women are citizens of Gielinor that can be found in many places across the world, usually alongside men. From a gameplay perspective, they are very similar to men, the only major differences being the appearance and name. They can be attacked, talked to, and pickpocketed.
Men and Women can be used to start Thieving by pickpocketing them at level 1. Each successful pickpocket gives 8 Thieving experience and 3 coins. Unsuccessful attempts result in a 5-second stun and 10 life points being taken. After the Lost Her Marbles caper from the Thieves' Guild, a successful pickpocket gives 20 coins.
There used to be an unresponsive woman at the top of the Lumbridge cellar house (where Learning the Ropes is completed). If talked to, the words "Nothing interesting happens" would appear. If you examined her, the text would appear as "She seems to doubt the existence of a dragon at all." This was likely an Easter egg that Jagex put in, as the dragon appeared in the cellar directly under the house. She has since been replaced by an attackable level 4 woman.
In Falador, there was a rich level 2 woman with the examine of "One of RuneScape's many citizens. She looks rich." The woman and her mansion were later replaced with the Party Room.
The level 4 women in West Ardougne are weak to fire spells, whereas level 4 women found everywhere else are weak to earth spells.