I designed my house based on usefulness and speed. The most useful rooms are placed near the entrance portal on the ground floor. My chapel and workshop are right next to the entrance portal, and all my portal chambers are very close as well. My chapel has a gilded altar with incense burners for raising prayer. I have 3 portal chambers so that when I am on Lunar Magic or Ancient Magicks, I am still able to use most of the normal magic teleports.
My house is currently located in Pollnivneach, because it is a very short walk from the slayer ring Pollnivneach teleport. Combined with my house portals, I do not need to use any teleport tablets at all.
My upper floor is where I placed all the rooms that I do not use or rarely use.