To get your daily helping of vis wax, you'll need to fill up the machine with three types of rune. You can put any type of rune into any of the slots - with the exception of Armadyl runes.
Putting different runes in different slots will yield differing amounts of vis wax when you click 'combine' on the interface. This amount changes daily, so you may wish to experiment first.
Experiment by filling up the machine with combinations of three runes. You'll see how much wax you would get with that combination, although if you try again the number or runes needed before clicking 'combine' will increase.
Each slot has a daily best-in-slot rune, determined randomly each day. Each slot also counts for a set proportion of the final amount of vis wax:
Slot 1 is the same rune for every player, and counts for 30%.
Slot 2 is one of three possible runes, and counts for 30%.
Slot 3 is randomly assigned to each player, and counts for 40%.
It's a good idea to talk to other players about the first and second slots. Sharing your research will help you get as much vis wax as you can, for as little cost in runes.
Vis Wax and its Many Uses
Vis wax[help] is marvellous stuff, with a variety of unique uses.
Click the vis wax in your inventory and you'll have a choice of three functions:
Extend the duration of most auras by 50 or 100%. One extension per cooldown period.
The Wisdom and Jack of Trades auras (all tiers) cannot be extended, but their cooldown can be reset once per day for a second activation.
The Festive, Enlightenment, Daemonheim, Oddball, and all other cosmetic auras are not affected by vis wax.
Reroll daily challenges directly from the Challenges interface. You'll be offered an alternative in a skill different to the original, or you'll be able to stick with what you had. Each challenge can only be rerolled once.
Some challenges can also be extended - doubling the action needed for twice the reward. Note that not every challenge is eligible for this.
Increase your daily gathering limit by 50% or 100%.
Altar Running Improvements
In addition to the Rune Goldberg machine, we've tweaked the following to make runecrafting at an altar a bit smoother:
Essence stored in pouches or in abyssal familiars will now be automatically used when crafting runes, alongside those in your ordinary inventory.
The abyssal titan and abyssal lurker have had their rune essence carrying capacities and summon durations increased.