The Sound of Guthix is a music track that is unlocked by going to the Ancient Guthix Temple during the While Guthix Sleeps quest. The songs that play in While Guthix Sleeps are widely considered to be the hardest to obtain, as While Guthix Sleeps has incredibly high skill requirements.
The song has a slow, methodical tempo from start to finish, with ever-increasing numbers of instruments coming in. It begins with a steady drum, rainstick, cymbal, and "voice" background, then the first melody comes in, a violin-type lyrical passage, that is repeated later. A marimba joins in the background and later, a similar "saxophone" melody to the "violin" earlier. After this, the piece is mostly repetitions of earlier melodies and harmonies until the end.