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Smite (Tier 3) was removed from RuneScape after an update, but still exists in-game for those who had obtained it.
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Smite (Tier 3) is obtained from the Zamorakian quartermaster or the Saradominist quartermaster for 150 Renown. A player can "Drink" this item and it is used immediately one time to hit 50% of the target's maximum health in damage. After the week 9 vote, the store price was reduced to 142 Renown.

The most damage this item can do is 50,000, in 5 hits of 10,000 against the Zamorakian siege beast and the Saradomin colossus, due to its damage cap.