Skull could refer to any of the following:
- Skull (item), an item with various uses
- Muddy skull, a quest item
- Skull Torch, a decoration a player can build in their POH
- Werewolf Skullball, an Agility related activity
- Skull sceptre, a player-made staff that is able to teleport to Barbarian Village
- Strange skull, one of the components required to make the staff
- Right skull half, an item used to make the full skull
- Left skull half, an item used to make the full skull
- Strange skull, one of the components required to make the staff
- Vecna skull, a Magic level boosting item
- Magic skullball, an item that has various things to say
- Animal skull, one of 2 quest items
- Lizard skull, headgear used for storing Summoning scrolls.
- Shade skull, an item used to make Necromancers staff
- Monkey skull, a rare item that can be used to make a blue face gorilla Greegree
- Sugar skull, a Halloween 2012 SoF food item
- Skull (status), a status that affected items kept on death (removed from the game after an update)
- Skulls, found in the Runespan
- Flaming skull, a vanity item
- Skull mask, a mask that could be obtained from Festival of the Dead
- The Skull, a region accessible through player-owned ports
- The Skulls, a gang led by Khrum, during Stolen Hearts
- Skull of Remembrance, an item used to replay cutscenes of The Death of Chivalry Quest
- Heroic skull, an item that grants prayer experience during The Bird and the Beast