Sanfew serum combines the properties of Super restore and Anti-poison potions. Level 65 Herblore and completion of Zogre Flesh Eaters is needed to make this potion. Mixing the potion gives 160 herblore experience.
Use
A complete Sanfew Serum can be used as a weapon against Nail beasts, causing significant damage. To use it as a weapon, right-click on the potion and select use, then click on a Nail beast. This should be done if a nail beast is attacking the follower in Temple Trekking.
Players cannot use the Assist System to make this potion.
Notable uses of Sanfew Serum include K'ril Tsutsaroth and the Dagannoth Kings due to their ability to save space on Anti-poison potions, although this benefit is negated if a player possess an Anti-poison totem. However, since the Evolution of Combat poison damage has drastically decreased, greatly reducing the usefulness of this potion considering the effort required to make them.
Price per Dose
| Item | GE price | Price per dose |
|---|---|---|
 Sanfew serum (1)
|
4,021 | 4,021 |
 Sanfew serum (2)
|
3,264 | 1,632 |
 Sanfew serum (3)
|
5,144 | 1,715 |
 Sanfew serum (4)
|
6,330 | 1,583 |
 Sanfew serum flask (6)
|
18,964 | 3,161 |
Creating
 | - |  | ||
|---|---|---|---|---|
| 60 XP | - | 5,144 | ||
| Requirements | ||||
| Herblore level | 65 | |||
 Partially complete: Zogre Flesh Eaters | ||||
 Members only | Yes | |||
| Materials | ||||
| Item | Quantity | Price | Total | |
 | Mixture - step 2 (1) | 1 | N/A | - |
 | Nail beast nails | 1 | 108 | 108 |
Sanfew serum is made by adding, in order, Unicorn horn dust, clean snake weed and Nail beast nails to an already made 3-dose Super restore potion. Partially completed Sanfew Serums are called Mixture - step 1 and Mixture - step 2, but are not drinkable in these forms.
Players therefore need to make sure that the unicorn horn dust is highlighted before clicking each of the vials to avoid accidentally drinking any of the Super restore. Since the intermediate potions are not drinkable, the same danger does not exist once the unicorn horn dust has been added.
Herblore experience is given for each addition of one of the secondary ingredients in this potion.
| Unicorn horn dust xp | Snake weed xp | Nail beast nails xp | Total xp |
|---|---|---|---|
| 47.5 | 52.5 | 60 | 160 |
Flask
This potion can be made into a Sanfew serum flask by using at least six doses of it with a Potion flask. Players do not need a specific level to turn potions into flasks.
Production costs
The data in this table is based on the Grand Exchange prices of a Super restore (3) (the primary ingredient) and secondary ingredients. It is accurate assuming all items are bought off of the Grand Exchange and the resulting three-dose potion is sold immediately afterward.
| Material cost | Profit/loss | Profit/xp |
|---|---|---|
| 3,883* | 1,261 | 7.88 |
*Note: Snake Weed is an untradeable item, so its value is subjective and has not been included in the calculation.
Prayer restoring potions
Lua error: bad argument #1 to 'formatNum' (NaN). If a potion is untradeable the price of the ingredients is used instead. Prayer points needs to be rounded down after using the formulas.
Extra amounts
| Item | Normal amount |
With Holy wrench
|
With Reverence
|
With Holy wrench and Reverence +
|
|---|---|---|---|---|
 Prayer potion |
317 | 337 |
Tier 1: 347
Tier 2: 367 |
Tier 1: 367
Tier 2: 387 |
 Super restore |
327 | 347 |
Tier 1: 357
Tier 2: 377 |
Tier 1: 377
Tier 2: 397 |
Sanfew serum | ||||
 Replenishment potion | ||||
 Super prayer |
416 | 436 |
Tier 1: 446
Tier 2: 466 |
Tier 1: 466
Tier 2: 486 |
 Prayer renewal |
545 | 575 |
Tier 1: 575
Tier 2: 595 |
Tier 1: 605
Tier 2: 625 |
 Super prayer renewal potion |
912 | 962 |
Tier 1: 972
Tier 2: 1011 |
Tier 1: 1022
Tier 2: 1061 |
