Poisonous may refer to:
- Poison, a detriment that players and monsters suffer when they are attacked by a poisoned weapon
- A term for any weapon that has any form of weapon poison on it
- Weapon poison, a potion made from kwuarm and dragon scale dust
- Karambwan paste, a type of poison created by crushing karambwan with a pestle and mortar
- Weapon poison+, a potion made from cactus spine and red spiders' eggs]
- Weapon poison++, a potion made from cave nightshade and poison ivy berries
- Poisonous blast scroll, a scroll that is needed for a stranger plant familiar to perform its special attack
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