During Cold War, players have to help the duo find instruments that they can play without thumbs so they can distract a KGP guard and allow the player access to the war room. After the player brings them some cowbells and a set of penguin bongos, the nearby guard comes and yells at them for the noise, allowing the player to sneak past. During Hunt for Red Raktuber, they help players compose a song to put the same guard to sleep so they can access the war room yet again. Once the song is composed, it puts the guard to sleep, and he begins to have nightmares about the penguin
During Some Like it Cold, the player finds the duo practising outside the KGP base, and they reveal that they were fully aware that the player was a human, but thought it was something they had to reveal on their own terms. Players then make them a pop costume and a rock costume so they can accompany the player to the Prisoner of Walrus Camp, as the seals of the camp are big fans of the duo, and will only allow the player there if Ping and Pong accompany them. Once on the camp, Ping and Pong hold a small concert to act as a distraction while the camp is blown up and Ping, Pong, the Player, Teddy, Larry, Astoria and Plaza escape on a submarine. Once back at shore, Chuck of the PBJ allows the two former KGP-associates to leave due to their help, provided that they never return to the iceberg. They agree to this, as they wish to go on tour.
Ping and Pong may also be a reference to Cheech and Chong, a stand-up comedy duo consisting of Richard "Cheech" Marin and Tommy Chong. Both act as hippie characters who just want to chill and play music. The striking similarity with Cheech & Chong is their laid-back behaviour which often leads to trouble for them, unintentionally, as they say during the quests.