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Mouse may refer to:
- Mouse, a level 61 monster that lives in the Mouse Hole in Taverley
- Mouse Hole, an area encountered during the Grim Tales quest
- Mouse toy, a fun weapon that players gain after completing A Tail of Two Cats
- Game controls, which includes information on using a mouse to control the game
- Toy mouse, a clockwork toy that players can make in the workshop of their player-owned house
- Cave mouse, used in Carnillean Rising