Most Wanted cards are items obtained in Rush of Blood. They have a chance of increasing the drop rates of a unique item for their respective monsters. Each card starts with 100 charges, and a charge is used for every monster of that type killed with the card in the inventory. If the card's influence obtains a rare drop, then extra charges will be consumed for that kill. It is possible for a rare drop to be obtained without the card's effect, in which case only 1 charge will be used, as normal. Only one card of each type may be owned at once. The odds of receiving any of the cards from Rush of Blood is , where is the number of waves completed for that run. Most Wanted cards can only be obtained during a rewards run, which is a weekly event that resets on Wednesdays.
- Most Wanted card (abyssal demons)
- Most Wanted card (automatons)
- Most Wanted card (glacors)
- Most Wanted card (tormented demons)