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For about 12 seconds Magic Imbue enables the caster to craft combination runes without needing to use opposing talismans. This spell looks like the "Bones to Bananas" spell or the "Bones to Peaches". The spell removes the requirement for a talisman to be present in the inventory at all; to craft combination runes after casting Magic Imbue, players must use the opposing runes on the Runecrafting altar. (For example, to create lava runes at the earth altar, players would use fire runes on the altar after casting Magic Imbue). This spell can be only cast once about every 12.6 seconds.
Combined with a steam battlestaff or mystic steam staff, Magic Imbue substantially reduces the cost of crafting combination runes, as some talismans can be quite expensive. On a related note, the difficulty of crafting dust, smoke and mist runes is reduced, as it becomes economically viable to craft these runes at the air altar outside Varrock, which is near a bank.
Note: The spell does not increase the only 50% chance of runes being crafted. You still need the binding necklace if you want all runes successfully crafted. Without it you will only have an estimated 50% success rate for crafting combination runes.