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Lizard may refer to:
- Any of three Slayer monsters located in the Kharidian Desert :
- Cave lizard, a monster native to the Ourania Caves
- Swamp lizard (Hunter), a creature caught using the Hunter skill
- Swamp lizard, a two handed Ranged weapon
- Lizard skull, a helmet used to store Summoning scrolls
- Desert lizard bone, A quest item received during Rag and Bone Man quest
- Ilujanka, a race also called Lizardmen