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Lion may refer to:
- The Shaikahan on Karamja
- Growler, one of Commander Zilyana's guards in the God Wars Dungeon
- The Saradominist prideleader fighting in the Battle of Lumbridge
- Sphinx, a half-lion creature in Sophanem
- Amascut, the goddess of rebirth and destruction, who previously took on the aspect of a lioness
- Companion pets: