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Hand may refer to:
- Hand (Back to my Roots), a wizard's severed hand found during the Back to my Roots quest
- Hand (Rocking Out), a part of a broken brass hand that is found to be in a reusable condition
- Giant's hand, a wieldable item received from Balthazar Beauregard's Big Top Bonanza
- Crawling Hand, a Slayer monster
- Skeletal Hand, a Slayer monster
- Zombie hand, a Slayer monster
- Creeping hand, a pet that can be rewarded at Soul Wars
- Hand Slot, the slot where gloves, bracelets and vambraces are shown when wielded
- Sandy hand, a wizard's severed hand, found during the Hand in the Sand quest