The Golem guard is encountered during the Missing My Mummyquest. It prevents access to the Pharaoh Queen's tomb and has to be killed in order to gain access. It does not appear again after the quest, with the exception of the broken Golem to the west of the temple which cannot be attacked.
Note: Formerly, only crush attacks and rings of recoil could damage the Golem. However following the Evolution of Combat, it is currently possible to kill it by other means.