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The Gnome Institute of Knowledge is a research organisation based within the Gnome Empire. The organisation is dedicated to performing both magical and scientific research to further the progress of the gnome race. The institute is only briefly mentioned several times in Gnomic Negotiations, a lore found on the official RuneScape website, and has not made an appearance in-game.

The only field of study expressly described in the story is psychology. Dr. Darius Gnomalus, who is interviewed by a human during the story, was Head of Psychology when the account was written several years ago. It is possible that he still holds the position today. Little else is known about the organisation.

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