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The Defence potion is a one dose potion only available in the Dungeoneering skill. Using the potion boosts a player's Defence level by 2.5 + 11% of their level.
It is made by adding Featherfoil and Void dust to a Vial of water. This requires level 42 Herblore and grants 89 experience in Herblore. This potion can only be made in dungeons with complexity level ≥5.