Assuming you have the best essence pouch configuration for your level, with or without an abyssal familiar, and nothing else in your inventory.

• Does not take into account the pouch cost for the familiar (Abyssal parasite pouch (1873 gp) Abyssal lurker pouch (5996 gp), Abyssal titan pouch (1962 gp) and Spirit graahk pouch (13977 gp)).
• Does not count for extra elemental runes crafted due to the Lumbridge effect
• Soul runes are not, of course, currently craftable in bulk, only as part of the ZMI mix.
• Shows profit per trip, NOT per hour
• In the long run a less profitable (per trip or per hour) rune may, by yielding more XP, pay off by getting the crafter to a more profitable level/rune combination faster. Or it may not.
• Does not take into account fractional rates, although these may balance out in terms of preference.
• Laws cannot be crafted using a familiar so be warned that the table for with familiar is wrong. You will need to take the number from the without familiar table.

As at 10 August 2012 the most profitable/smallest loss runes to craft were

• 1-13: air (loss; earth is equal for 9-10)
• 14-26: fire (loss; air is equal for 22-26)
• 27-34: cosmic
• 35-39: fire (cosmic if you are using pure essence)
• 40-53: astral
• 54-58: law
• 59-64: cosmic
• 65-99: death

If you make an abyssal trip for pouch repair, this table is a sound guide.

Without familiarEdit

With familiarEdit