A Bowl of milk, honey and guam is used during the Meeting History quest as a medicine for Baby Sarah to cure her illness.
This item is obtained by using a special bowl with the beehive in the family's backyard, creating a bowl of honey. Then, a bucket of milk is then added, making a bowl of milk and honey. Finally, by grinding a guam leaf with a pestle and mortar, players can obtain ground guam to be added to the bowl and players will obtain the cure to Sarah's illness.
After his daughter is cured, Roger happily narrates the story about how humans arrived on Gielinor through the Portal of Life.