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Blood essences are pocket slot items with combat benefits unlocked after River of Blood, made using potions and congealed blood. The ability to make them is unlocked by reading Haemalchemy (Vol. 2), obtained by speaking to Vanescula Drakan on top of Castle Drakan after completion of River of blood. Vanescula will then give one of them for free, this completes the achievement Paint it Red.

Blood essences are created with 1,000 charges (including the free one from Vanescula). Additional charges can be added by using more congealed blood - 10 charges each - to a maximum of 5,000 charges. Once the charges are completely exhausted, the benefits of the essence cannot activate, but it can still be worn. Upon death, if recovered from a gravestone and not protected, essences lose 1,000 charges. Destroying an essence also destroys all of its remaining charges.

Blood essences have 2 functions when worn in combat: a passive effect, which occurs randomly in combat with a weak benefit, and a much stronger version of the effect which can be activated at any time from a right-click option when worn. Activated effects have a 1 minute cooldown period where it cannot be activated again; this is shared over all essences - except the tireless blood essence, which has a 2 minute cooldown shared with adrenaline/replenishment potions instead. Each time the passive effect occurs, 1 charge is drained; each use of the active effect drains 50 charges.

Each passive occurrence costs 3.8 coins, and each activation costs 190 coins.

Essences

Blood essences are made by using 100 congealed blood on a specific potion. They also require a number of vyre corpse cremations.

Essence Vyre corpses Potion Passive effect Activated effect
Vampyric blood essence Vampyric blood essence 0 Super Zamorak brew (4) Super Zamorak brew (4) Each melee hit dealt has a chance to heal 2.5% of damage dealt, to a maximum of 250 per hit The next melee hit dealt within 20 seconds heals 25% of damage dealt, up to 2500
Penance blood essence Penance blood essence 100 Super Guthix rest (4) Super Guthix rest (4) Chance of taking 8% more damage (increased by a minimum of 4 and a maximum of 100), restoring prayer points for 25% of the extra damage taken The next hit taken within 20 seconds deals 80% more damage (increased by a minimum of 200 and a maximum of 1000), restoring prayer points for 25% of the extra damage taken
Aegis blood essence Aegis blood essence 200 Guthix balance (4) Guthix balance (4) Chance of reducing incoming damage by 5% (by a minimum of 5 and a maximum of 250) The next hit taken within 20 seconds is reduced by 50% (by a minimum of 50 and a maximum of 2500)
Reflecting blood essence Reflecting blood essence 300 Super Saradomin brew (4) Super Saradomin brew (4) Each hit taken has a chance to apply a 6-second buff which reflects 5% of damage taken, to a maximum of 250 per hit The next hit taken within 20 seconds is 50% reflected (by a minimum of 50 and a maximum of 2500) in addition to applying the passive's 6-second buff
Berserk blood essence Berserk blood essence 400 Weapon poison++ (4) Weapon poison++ (4) Each hit taken has a chance to apply a 14% + 2 level boost to the relevant offensive skill (based on main-hand weapon) for 4 seconds; stacks with boosting potions, but will not activate when under the effect of an overload (or variant) Applies a 14% + 2 level boost to the relevant offensive skill (based on main-hand weapon) for 20 seconds; stacks with boosting potions, but will not activate when under the effect of an overload (or variant)
Tireless blood essence Tireless blood essence 500 Super restore (4) Super restore (4) Chance of restoring adrenaline when a monster is killed; amount based on the monster's maximum life points - a maximum of 2% adrenaline restored Instantly restores 15% adrenaline. Two-minute cooldown, shared with adrenaline/replenishment potions.

Similar effects

Cost

Using Grand Exchange as base price, the following table shows the cost to produce each blood essence:

Primary Cost Secondary Cost Total Result
Super Zamorak brew (4) Super Zamorak brew (4) 9,809 100 x Congealed blood 1000 Congealed blood 3,800 13,609 Vampyric blood essence Vampyric blood essence
Super Guthix rest (4) Super Guthix rest (4) 6,026 9,826 Penance blood essence Penance blood essence
Guthix balance (4) Guthix balance (4) 2,609 6,409 Aegis blood essence Aegis blood essence
Super Saradomin brew (4) Super Saradomin brew (4) 67,715 71,515 Reflecting blood essence Reflecting blood essence
Weapon poison++ (4) Weapon poison++ (4) 25,771 29,571 Berserk blood essence Berserk blood essence
Super restore (4) Super restore (4) 2,894 6,694 Tireless blood essence Tireless blood essence