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For the potion flask version, see Antipoison++ flask.
[FAQ] • [doc]
Antipoison++ detail

Antipoison++ are made by mixing clean irit and magic roots in a vial of coconut milk, requiring 79 Herblore and giving 177.5 Herblore experience.

Super strong anti-poison potions cure poison and provide the longest possible immunity to poison, which is 12 minutes. This makes them far more useful than other types of anti-poisons, eliminating the need to drink constantly.

This potion is rarely made through Herblore, because the ingredients cost significantly more than the finished potion. However, it is dropped from several monsters as well as obtained as a reward from elite clue scrolls, which is enough to satisfy the demand. For example, the Corporeal Beast drops it in stacks of 40. Much of the demand for it comes from people doing Araxxor, training on the guards or doing the quest on Ape Atoll, or killing wyverns. Another common use is for the Pyramid Plunder activity.

If your antipoison is about to run out you'll get the message: "Your immunity to poison is about to expire."

Price per DoseEdit

Item GE price Price per dose
Antipoison++ (1) Antipoison++ (1) 793 793
Antipoison++ (2) Antipoison++ (2) 1,628 814
Antipoison++ (3) Antipoison++ (3) 11,418 3,806
Antipoison++ (4) Antipoison++ (4) 14,000 3,500


Antipoison++ (4) Antipoison++ (4)
Herblore-Make-X GE icon
177.5 XP-14,000
Herblore Herblore level79
P2P icon Members onlyYes
Antipoison++ (unf)Antipoison++ (unf)1N/A-
Magic rootsMagic roots18,8408,840


This potion can be made into an antipoison++ flask by using at least six doses of it with a potion flask. Players do not need a specific level to turn potions into flasks.

Production costsEdit

Herb Material cost Profit Profit/XP
Clean irit Clean irit 18,369-6,951-39.16
Grimy irit Grimy irit 18,239-6,821-36.61
Grimy iritClean irit + Coconut milk = Antipoison++ (unf)

Grimy irit is cleaned to become clean irit added to a vial of coconut milk to make antipoison++ (unf)

Antipoison++ (unf) + Magic roots = Antipoison++ (3)
Then add magic roots to make a 4-dose Antipoison++.

Antipoison protection comparisonEdit

  • Prices based on price for (3) dose potions. Expect some variation when buying potions decanted to other dose counts.
Antipoison Price/dose Seconds/dose Price/second
Antipoison (4) Antipoison 77 86 0.9
Super antipoison (4) Super antipoison 1,147 346 3.32
Antipoison+ (4) Antipoison+ 663.67 518 1.28
Antipoison++ (4) Antipoison++ 3,806 720 5.29
Sanfew serum (4) Sanfew serum 1,827.33 86 21.25

Drop sourcesEdit

Antipoison++ potion (4)Edit

This list was created dynamically. For help, see the FAQ.
To force an update of this list, click here.
For an exhaustive list of all known sources for this item, see here.
Source Combat level Quantity Rarity
Corporeal Beast78540Uncommon


[FAQ] • [doc]

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