For the potion flask version, see Antipoison++ flask.
[FAQ] • [doc]
Antipoison++ detail

Antipoison++ are made by mixing clean irit and magic roots in a vial of coconut milk, requiring 79 Herblore and giving 177.5 Herblore experience.

Antipoison++ cures poison and provide the longest possible immunity to poison, which is 12 minutes. This makes them far more useful than other types of antipoison potions, eliminating the need to drink constantly.

If your antipoison is about to run out you'll get the message: "Your immunity to poison is about to expire."

Price per DoseEdit

Item GE price Price per dose
Antipoison++ (1) Antipoison++ (1) 1,229 1,229
Antipoison++ (2) Antipoison++ (2) 2,396 1,198
Antipoison++ (3) Antipoison++ (3) 4,290 1,430
Antipoison++ (4) Antipoison++ (4) 3,224 806
Antipoison++ flask (6) Antipoison++ flask (6) 14,812 2,469


Antipoison++ (4) Antipoison++ (4)
Herblore-Make-X GE icon
177.5 XP-3,224
Herblore Herblore level79
P2P icon Members onlyYes
Antipoison++ (unf)Antipoison++ (unf)1N/A-
Magic rootsMagic roots15,3815,381


This potion can be made into an antipoison++ flask by using at least six doses of it with a potion flask. Players do not need a specific level to turn potions into flasks.

Production costsEdit

Herb Secondary Vial Material cost Profit Profit/XP
Clean irit Clean irit Magic roots Magic roots Coconut milk Coconut milk 14,284 -9,994 -55.99
Grimy irit Grimy irit Magic roots Magic roots Coconut milk Coconut milk 14,233 -9,943 -53.09
N/A Magic roots Magic roots Irit potion (unf) Irit potion (unf) 9,282 -4,992 -28.12
Grimy iritClean irit + Coconut milk = Antipoison++ (unf)

Grimy irit is cleaned to become clean irit added to a vial of coconut milk to make antipoison++ (unf)

Antipoison++ (unf) + Magic roots = Antipoison++ (3)
Then add magic roots to make a 4-dose Antipoison++.

Antipoison protection comparisonEdit

  • Prices based on price for (3) dose potions. Expect some variation when buying potions decanted to other dose counts.
Antipoison Price/dose Seconds/dose Price/second
Antipoison (4) Antipoison 154.67 86 1.8
Super antipoison (4) Super antipoison 1,222 346 3.53
Antipoison+ (4) Antipoison+ 875.33 518 1.69
Antipoison++ (4) Antipoison++ 1,430 720 1.99
Sanfew serum (4) Sanfew serum 1,757.67 86 20.44

Drop sourcesEdit

Antipoison++ potion (4)Edit

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For an exhaustive list of all known sources for this item, see here.
Source Combat level Quantity Rarity
Corporeal Beast78540Uncommon


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