Akrisae's set effect, Akrisae's Doom, gives him the chance to drain the player's prayer in a similar manner to that of a player wearing an entire set of Guthan the Infested's equipment. When a player not using prayer attacks him and the effect activates, he will say "Ahh, more prayers.". Akrisae attacks using magic with a maximum hit of 1800, and is very accurate, so Protect from Magic/Deflect Magic is advised. Akrisae only uses his magic attack within melee range, so using a stunning ability such as Binding Shot or Impact is very effective in reducing damage. Akrisae also uses protection prayers in accordance to what the player is using - after being dealt with 1500 damage in one combat style, he will immediately pray towards that style, requiring the player to use another combat style to defeat him. Players can hit over the damage cap if they hit fast enough, such as shooting a bolt from a crossbow and then using a quick ability to deal high amounts of damage before he can switch prayers. The ability Smash can temporarily disable his prayers.
Players who have completed the Ritual of the Mahjarrat will be placed in an instance of Verac's tomb. This is because his tomb will not appear to players who have not completed it. However, even if you haven't completed the quest, you can still see him in the catacombs.
There is currently a glitch where if the player uses Destroy or Asphyxiate, Akrisae will not calculate the first hit into his prayer mechanics. This means if the player uses one of these abilities (provided he is not protecting against that ability's combat style), the first hit can do damage, but will not force him to change his protection prayers until the second hit is calculated.
When Akrisae appears at the rewards chest, he will say 'You dare steal from us?' with a question mark, unlike the other 6 brothers.
He may rarely appear during the fight with Gregorovic. It is unknown if there are any conditions to have him appear.
He is the only Barrows brother not to appear in Sliske's Endgame as the developers had forgotten that he existed.